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May 2023

Low intracranial pressure (ICP) could play a role in the development of glaucoma among patients who have normal intraocular pressure (IOP), according to a new study.

Image of an animated purple brain


The Lithuanian-led study, published in Diagnostics,1 examined 80 normal tension glaucoma (NTG) patients, with the aim of assessing the relationship between ICP and visual field zones.

As well as IOP and ICP, scientists calculated the difference between the pressure in the eye and the pressure in the brain, known as the translaminar pressure difference.

The researchers found that low brain pressure was associated with more significant changes to a patient’s visual field, especially in the nasal zone.

The study's authors highlighted that further research is required to understand the role of intracranial pressure as a potential biomarker in NGT patients.

“These data support additional studies to reveal the mechanistic involvement of ICP in glaucoma pathophysiology, especially as a potential biomarker for NTG,” the study authors said.

This article has been republished courtesy of Mivision


1. Stoskuviene, A., Siaudvytyte, L., Januleviciene, I., et al., The Relationship between Intracranial Pressure and Visual Field Zones in Normal-Tension.